The Cell presents current comprehensive science in a readable and cohesive text that students can master in the course of one semester. This new edition retains the overall organization, themes, and special features of the Fourth Edition, including Key Experiment and Molecular Medicine essays, chapter sidebars that highlight areas of interest and clinical applications, and end-of-chapter questions with answers at the back of the book. The Fifth Edition has been updated throughout to reflect major advances since publication of the Fourth Edition in 2006, including: (1) Advances in understanding gene regulation by microRNAs; (2) Histones and epigenetic inheritance; (3) Identification of human disease susceptibility genes by genome-wide association scans; (4) Protein import into mitochondria; (5) Induced pluripotent stem cells; (6) Role of autophagy in programmed cell death; (7) Genomic analysis of mutations in human cancers; (8) New Key Experiments: RNA Interference (Chapter 4) and G Protein-Coupled Receptors and Odor Detection (Chapter 15).