Genome science has matured as a discipline to the point where it is now incorporated as a regular part of the genetics curriculum in universities. A Primer of Genome Science, Third Edition bridges the gap between standard genetics textbooks and highly specialized, technical, and advanced treatments of the subdisciplines. It provides an affordable and up-to-date introduction to the field that is suited to advanced undergraduate or early graduate courses. Bioinformatic principles and experimental strategies are explained side-by-side with the experimental methods, establishing a framework that allows teachers to explore topics and the literature at their own pace. The Primer is organized into six chapters dealing with the scope of genomics, genome sequencing, variation and complex traits, gene expression, proteomics, and metabolomics. Each chapter includes several boxes explaining the theory behind bioinformatic methods, discussion questions, and a summary. This edition has been updated to include the latest developments in next-generation sequencing, high-volume genotyping and expression profiling, and advances in metabolomics.